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Showing 1 to 12 of 716 entries
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Intra-articular decorin influences the fibrosis genetic expression profile in a rabbit model of joint contracture.

Bone & joint research

Abdel MP, Morrey ME, Barlow JD, Grill DE, Kolbert CP, An KN, Steinmann SP, Morrey BF, Sanchez-Sotelo J.
PMID: 24671942
Bone Joint Res. 2014 Mar 26;3(3):82-8. doi: 10.1302/2046-3758.33.2000276. Print 2014.

OBJECTIVES: The goal of this study was to determine whether intra-articular administration of the potentially anti-fibrotic agent decorin influences the expression of genes involved in the fibrotic cascade, and ultimately leads to less contracture, in an animal model.METHODS: A...

The effect of implant position on bone strain following lateral unicompartmental knee arthroplasty: A Biomechanical Model Using Digital Image Correlation.

Bone & joint research

Ali AM, Newman SDS, Hooper PA, Davies CM, Cobb JP.
PMID: 28855192
Bone Joint Res. 2017 Aug;6(8):522-529. doi: 10.1302/2046-3758.68.BJR-2017-0067.R1.

OBJECTIVES: Unicompartmental knee arthroplasty (UKA) is a demanding procedure, with tibial component subsidence or pain from high tibial strain being potential causes of revision. The optimal position in terms of load transfer has not been documented for lateral UKA....

A new bromelain-based enzyme for the release of Dupuytren's contracture: Dupuytren's enzymatic bromelain-based release.

Bone & joint research

Rubin G, Rinott M, Wolovelsky A, Rosenberg L, Shoham Y, Rozen N.
PMID: 27174554
Bone Joint Res. 2016 May;5(5):175-7. doi: 10.1302/2046-3758.55.BJR-2016-0072.

OBJECTIVES: Injectable Bromelain Solution (IBS) is a modified investigational derivate of the medical grade bromelain-debriding pharmaceutical agent (NexoBrid) studied and approved for a rapid (four-hour single application), eschar-specific, deep burn debridement. We conducted an ex vivo study to determine...

Augmented reality in bone tumour resection: An experimental study.

Bone & joint research

Cho HS, Park YK, Gupta S, Yoon C, Han I, Kim HS, Choi H, Hong J.
PMID: 28258117
Bone Joint Res. 2017 Mar;6(3):137-143. doi: 10.1302/2046-3758.63.BJR-2016-0289.R1.

OBJECTIVES: We evaluated the accuracy of augmented reality (AR)-based navigation assistance through simulation of bone tumours in a pig femur model.METHODS: We developed an AR-based navigation system for bone tumour resection, which could be used on a tablet PC....

Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model.

Bone & joint research

Cheng NT, Guo A, Cui YP.
PMID: 27301478
Bone Joint Res. 2016 Jun;5(6):218-24. doi: 10.1302/2046-3758.56.BJR-2015-0001.

OBJECTIVES: Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects....

Combination of modified mixing technique and low frequency ultrasound to control the elution profile of vancomycin-loaded acrylic bone cement.

Bone & joint research

Wendling A, Mar D, Wischmeier N, Anderson D, McIff T.
PMID: 26843512
Bone Joint Res. 2016 Feb;5(2):26-32. doi: 10.1302/2046-3758.52.2000412.

OBJECTIVES: The objective of this study was to determine if combining variations in mixing technique of antibiotic-impregnated polymethylmethacrylate (PMMA) cement with low frequency ultrasound (LFUS) improves antibiotic elution during the initial high phase (Phase I) and subsequent low phase...

Sagittal alignment of the spine-pelvis-lower extremity axis in patients with severe knee osteoarthritis: A radiographic study.

Bone & joint research

Wang WJ, Liu F, Zhu YW, Sun MH, Qiu Y, Weng WJ.
PMID: 27231331
Bone Joint Res. 2016 May;5(5):198-205. doi: 10.1302/2046-3758.55.2000538.

OBJECTIVES: Normal sagittal spine-pelvis-lower extremity alignment is crucial in humans for maintaining an ergonomic upright standing posture, and pathogenesis in any segment leads to poor balance. The present study aimed to investigate how this sagittal alignment can be affected...

Surrogate markers of long-term outcome in primary total hip arthroplasty: A systematic review.

Bone & joint research

Malak TT, Broomfield JA, Palmer AJ, Hopewell S, Carr A, Brown C, Prieto-Alhambra D, Glyn-Jones S.
PMID: 27267795
Bone Joint Res. 2016 Jun;5(6):206-14. doi: 10.1302/2046-3758.56.2000568.

OBJECTIVES: High failure rates of metal-on-metal hip arthroplasty implants have highlighted the need for more careful introduction and monitoring of new implants and for the evaluation of the safety of medical devices. The National Joint Registry and other regulatory...

Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis.

Bone & joint research

Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H.
PMID: 25977571
Bone Joint Res. 2015 May;4(5):84-92. doi: 10.1302/2046-3758.45.2000378.

OBJECTIVES: Salubrinal is a synthetic agent that elevates phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) and alleviates stress to the endoplasmic reticulum. Previously, we reported that in chondrocytes, Salubrinal attenuates expression and activity of matrix metalloproteinase 13...

Possible association of single nucleotide polymorphisms in the 3' untranslated region of HOXB9 with acetabular overcoverage.

Bone & joint research

Sekimoto T, Kurogi S, Funamoto T, Ota T, Watanabe S, Sakamoto T, Hamada H, Chosa E.
PMID: 25833894
Bone Joint Res. 2015 Apr;4(4):50-5. doi: 10.1302/2046-3758.44.2000349.

OBJECTIVES: Excessive acetabular coverage is the most common cause of pincer-type femoroacetabular impingement. To date, an association between acetabular over-coverage and genetic variations has not been studied. In this study we investigated the association between single nucleotide polymorphisms (SNPs)...

Criteria for preserving posterior cruciate ligament depending on intra-operative gap measurement in total knee replacement.

Bone & joint research

Kaneyama R, Otsuka M, Shiratsuchi H, Oinuma K, Miura Y, Tamaki T.
PMID: 24719296
Bone Joint Res. 2014 Apr 09;3(4):95-100. doi: 10.1302/2046-3758.34.2000228. Print 2014.

OBJECTIVES: Because posterior cruciate ligament (PCL) resection makes flexion gaps wider in total knee replacement (TKR), preserving or sacrificing a PCL affects the gap equivalence; however, there are no criteria for the PCL resection that consider gap situations of...

Does bone compaction around the helical blade of a proximal femoral nail anti-rotation (PFNA) decrease the risk of cut-out?: A subject-specific computational study.

Bone & joint research

Goffin JM, Pankaj P, Simpson AH, Seil R, Gerich TG.
PMID: 23673407
Bone Joint Res. 2013 May 01;2(5):79-83. doi: 10.1302/2046-3758.25.2000150. Print 2013.

OBJECTIVES: Because of the contradictory body of evidence related to the potential benefits of helical blades in trochanteric fracture fixation, we studied the effect of bone compaction resulting from the insertion of a proximal femoral nail anti-rotation (PFNA).METHODS: We...

Showing 1 to 12 of 716 entries